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Generic Name: Prochlorperazine Tablets (pro-klor-PURR-uh-zeen)
Brand Name: Compazine
Prochlorperazine is used for:
Controlling severe nausea and vomiting and treating schizophrenia.
It is also used for the short-term (4 weeks) treatment of
generalized nonpsychotic anxiety. It may also be used for
other conditions as determined by your doctor.
Prochlorperazine is a phenothiazine. It works by blocking
a certain chemical (dopamine) in the brain.
Do NOT use Prochlorperazine if:
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you are allergic to any ingredient in Prochlorperazine
or similar medicines |
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you are taking astemizole, cisapride, or terfenadine
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you have severe central nervous system depression |
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Contact
your doctor or health care provider right away if any
of these apply to you. |
Before using Prochlorperazine:
Some medical conditions may interact with Prochlorperazine.
Tell your doctor or pharmacist if you have any medical conditions,
especially if any of the following apply to you:
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if you are pregnant, planning to become
pregnant, or are breast-feeding |
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if you are taking any prescription or nonprescription
medicine, herbal preparation, or dietary supplement |
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if you have allergies to medicines, foods, or other
substances |
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if you have a history of heart disease, central nervous
system depression, blood problems, liver problems, low
blood pressure, increased pressure in the eye, neuroleptic
malignant syndrome, tardive dyskinesia, bone marrow problems,
unusual muscle movements, Parkinson disease, a predisposition
to glaucoma, Reye syndrome, prostate problems, or seizures,
or you have alcoholism |
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Some MEDICINES
MAY INTERACT with Prochlorperazine. Tell your health
care provider if you are taking any other medicines,
especially any of the following: |
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Anticholinergics (eg, diphenhydramine, oxybutynin, scopolamine)
or lithium because they may decrease Prochlorperazine's
effectiveness |
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Angiotensin-converting enzyme (ACE) inhibitors (eg,
enalapril), anticholinergics (eg, diphenhydramine, oxybutynin,
scopolamine), general anesthetics (eg, thiopental), haloperidol,
methyldopa, or tricyclic antidepressants (eg, amitriptyline)
because the risk of side effects, such as seizures, may
be increased |
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ACE inhibitors (eg, enalapril), anticholinergics (eg,
diphenhydramine, oxybutynin, scopolamine), astemizole,
cisapride, dofetilide, haloperidol, hydantoins (eg, phenytoin),
methyldopa, metrizamide, naltrexone, polypeptide antibiotics
(eg, actinomycin), serotonin receptor antagonist antiemetics
(eg, ondansetron), terfenadine, tramadol, trazodone, or
tricyclic antidepressants (eg, amitriptyline) because
the risk of their side effects may be increased by Prochlorperazine
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Bromocriptine, guanethidine, levodopa, or pergolide
because their effectiveness may be decreased by Prochlorperazine
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Lithium because unexpected toxic effects may occur |
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This may
not be a complete list of all interactions that may
occur. Ask your health care provider if Prochlorperazine
may interact with other medicines that you take. Check
with your health care provider before you start, stop,
or change the dose of any medicine. |
How to use Prochlorperazine:
Use Prochlorperazine as directed by your doctor. Check the
label on the medicine for exact dosing instructions.
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Take Prochlorperazine by mouth with or without
food. If stomach upset occurs, take with food to reduce
stomach irritation. |
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If you miss a dose of Prochlorperazine, take it as soon
as possible. If you are taking 1 dose at bedtime and do
not remember until the next morning, skip the missed dose
and go back to your regular dosing schedule. |
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Ask your
health care provider any questions you may have about
how to use Prochlorperazine. |
Important safety information:
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Prochlorperazine may cause drowsiness, dizziness,
blurred vision, or lightheadedness. These effects may
be worse if you take it with alcohol or certain medicines.
Use Prochlorperazine with caution. Do not drive or perform
other possibly unsafe tasks until you know how you react
to it. |
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Prochlorperazine may cause dizziness, lightheadedness,
or fainting; alcohol, hot weather, exercise, or fever
may increase these effects. To prevent them, sit up or
stand slowly, especially in the morning. Sit or lie down
at the first sign of any of these effects. |
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Do not drink alcohol or use medicines that may cause
drowsiness (eg, sleep aids, muscle relaxers) while you
are using Prochlorperazine; it may add to their effects.
Ask your pharmacist if you have questions about which
medicines may cause drowsiness. |
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Tell your doctor or dentist that you take Prochlorperazine
before you receive any medical or dental care, emergency
care, or surgery. |
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Prochlorperazine may cause you to become sunburned more
easily. Avoid the sun, sunlamps, or tanning booths until
you know how you react to Prochlorperazine. Use a sunscreen
or wear protective clothing if you must be outside for
more than a short time. |
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Avoid exposure to extreme heat while taking Prochlorperazine.
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Patients who will be having spinal cord surgery should
stop using Prochlorperazine at least 48 hours before surgery.
Do not use Prochlorperazine for at least 24 hours after
surgery and do not use it to control nausea and vomiting
that has occurred before or after surgery. |
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Neuroleptic malignant syndrome (NMS) is a possibly fatal
syndrome that can be caused by Prochlorperazine. Symptoms
may include fever; stiff muscles; confusion; abnormal
thinking; fast or irregular heartbeat; and sweating. Contact
your doctor at once if you have any of these symptoms.
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Use Prochlorperazine with caution in the ELDERLY; they
may be more sensitive to its effects. |
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Prochlorperazine should not be used in CHILDREN who
are having surgery, who are younger than 2 years old,
or who weigh less than 20 pounds; safety and effectiveness
in these children have not been confirmed. |
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PREGNANCY and BREAST-FEEDING: If you become pregnant,
contact your doctor. You will need to discuss the benefits
and risks of using Prochlorperazine while you are pregnant.
Prochlorperazine is found in breast milk. If you are or
will be breast-feeding while you use Prochlorperazine,
check with your doctor. Discuss any possible risks to
your baby. |
Possible side effects of Prochlorperazine:
All medicines may cause side effects, but many people have
no, or minor, side effects. Check with your doctor if any
of these most COMMON side effects persist or become bothersome:
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Blurred vision; chills; constipation; dizziness;
drowsiness; dry mouth; jitteriness; nasal congestion;
sleeplessness. |
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Seek medical
attention right away if any of these SEVERE side effects
occur: |
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Severe allergic reactions (rash; hives; itching; difficulty
breathing; tightness in the chest; swelling of the mouth,
face, lips, or tongue); agitation; altered mental abilities,
including lack of response to your surroundings; changes
in breasts; changes in menstrual period; changes in vision;
difficulty swallowing; drooling; excessive sweating; fever;
inability to move eyes; increased body heat; involuntary
movements of tongue, face, mouth, or jaw (eg, protrusion
of tongue, puffing of cheeks, puckering of mouth, chewing
movements); irregular or fast heartbeat; mask-like face;
muscle stiffness; muscle spasms of face, neck, or back;
prolonged or painful erection; restlessness; rigid muscles;
shuffling walk; sore throat; tension in legs; tremors;
twitching or twisting movements; unusual eye movements;
weakness of arms or legs; yellowing of the skin or eyes. |
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